Despite the Germanwings disaster, I'd still take two pilots over one for a commercial air flight. Two pilots/aircrew routinely catch each other's mistakes, whether it is as a wingman, or as two crew in the same aircraft. It's similar to engines in that having only one is inherently less safe, no matter how reliable that engine is. Reliability becomes the bigger issue with more lives on the line, or more expensive platforms. You wouldn't want to have an expensive single engine aircraft flying off the boat during blue water ops, would you? Oh, wait...
But seriously- with respect to single vs. two pilot aircraft, public acceptance is only part of the issue. While it can be statistically shown that single-piloted aircraft have a higher incident/mishap rate than two-piloted aircraft, seeing two pilots up front during boarding is also something that makes people flying commair "feel" safer, even if they don't know jack about aviation. So you have both public acceptance AND empirical evidence to overcome in order to get down to 1 person in the cockpit. In my opinion, that's not a reasonable barrier for airlines in the foreseeable future.