I would assume that the high disc loading of the smaller proprotor would put you at a disadvantage compared to a similar sized aircraft with a traditional rotor system such as a Chinook.
I could see the Army in 20 years having the S-97 as a scout, the V-280 as medium-lift and attack and the venerable CH-47 as heavy lift - none of which have a tail-rotor. Using 25% of your power to simply keep from spinning has always seemed like a waste...
If the Army is still using manned scout aircraft in 20 years, god help them. They're almost an anachronism NOW.