Like Wink said, figuring out a consistent instructor will be helpful. A base club can be more stable because a lot of times it's retirees that are the CFIs. Don't expect them all to be former military pilots, though. I flew with one at Jax that was a retired P-3 FE.
Availability will be another issue. Whatever scheduling system the place has, ask to look at it so you can see how far out you have to schedule/plan to get both a CFI and a plane. Planes may be more available than CFIs, and both may be unavailable on weekends.
I would plan on flying no less than once a week, as Skybert said, it can cost you more money in the long run if you do it infrequently. That doesn't mean if something comes up you'll forget everything in a week, but initial muscle memory and consistency are EXTREMELY helpful, no matter how many hours you have. I would also recommend not doing two days in a row, at least initially. Figure out your mental stamina, which will increase after your first few flights.
Grizz mentioned ground school. Personally, I'd recommend doing some flying first before doing dedicated ground school. It will help in applying the concepts in the class. You'll get short pieces of ground instruction during every lesson, but it won't be the official ground school training.
Lastly, remember to have fun!