Or you could make a stop at some college campuses to partake in the scenery...UVA, VT, JMU, UNC, Duke, NC State, Clemson, UGA, UF, FSU are all within striking distance.
No love for the alma mater?
I'd personally do the Charleston/Savannah route just for the riverfront life and the golf since my quest for plentiful southeastern forktail is over.
I ended up doing a full dity with not a lot of time so we did 95/85/65 through Durham, Charlotte, Atl and Montgomery. Although I claim Atl as a second home, I hate that route, but it's the fastest.